12/6/2023 0 Comments Transient global amnesia causesThere is also evidence for an association between TGA recurrence and a family or personal history of migraine, as well as a personal history of depression ( 4). Interestingly, patients with TGA recurrence were found to be younger ( 8). A recent systematic review, evaluating nine cohort studies with a total of 1,989 patients, reported an overall recurrence rate of 13.5% ( 4), although single studies showed a wide variation (from 5.4 to 27.1%) ( 6, 7). Typically, TGA occurs as a single event, but recurrences are occasionally described with up to 11 TGA episodes anecdotally reported in one patient ( 5). The cause of this neuropsychological syndrome with foreground anterograde and retrograde amnesia without focal neurological deficits is thought to reflect a transient deficit in hippocampal function ( 2) and a reversible disturbance in the functional connectivity of the broader episodic memory network including the medial temporal sub-network, as well as the orbitofrontal-cingulate, medial occipital, inferior temporal and deep-structure sub-networks ( 3, 4). Transient global amnesia (TGA), first described in 1956 ( 1), is an acute disturbance of memory function for a period of less than 24 h that usually occurs in middle-aged and elderly individuals. In turn, pre-existing cerebrovascular pathology, in the form of chronic hypertension and cerebral microangiopathy, seems to counteract TGA recurrence. A 24.5% risk of subsequent TGA recurrence in the following five years was determined for TGA patients up to 70 years of age without microangiopathic changes on MRI (Fazekas' score 0).Ĭonclusion: Younger TGA patients without significant microangiopathy do have an increased recurrence risk. In a subgroup analysis, patients with at least five years of follow-up ( N = 160, median follow-up period 7.0 ± 1.4 years) had a recurrence rate of 11.3%. The mean latency to recurrence was 3.0 years ± 2.1 years after the first episode. 67.3 ± 10.5 years, p = 0.032) and showed a lower degree of cerebral microangiopathy compared to TGA patients without recurrence. Results: TGA patients with subsequent recurrence were significantly younger (recurrent vs. Comparisons were made between TGA patients with and without subsequent recurrence. The median follow-up period amounted to 4.5 ± 2.7 years. Methods: Cardiovascular risk profile and magnetic resonance imaging (MRI) of 340 hospitalized TGA patients between 20 were retrospectively analyzed. This retrospective study aimed to determine predictors for TGA recurrence. Prevalence rates of recurrent TGA vary widely from 5.4 to 27.1%. TGA occurs as a single event in most cases. Background: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of less than 24 h.
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